Pyruvate Dehydrogenase E1 α rabbit mAb

A23924
Size
  • 50ul
  • 100ul
Price
  • $129
  • $229
Qty
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Product description

Source
Rabbit
Applications
WB;IHC;IF;IP;ELISA
Reactivity
Human; Mouse; Rat
Dilution
IHC 1:200-1:1000, WB 1:1000-1:5000, IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200,
Storage
-20°C/1 year
Specificity
endogenous
Source/Purification
Protein A
Uniprot No
P08559
Alternative names
PDHA1 ODPA
Background
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Other
PDHA1;PHE1A;Pyruvate dehydrogenase E1 component subunit alpha; somatic form, mitochondrial;PDHE1-A type I
Mol.Wt (Da)
43kD

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